Hyperhidrosis and human leukocyte antigens in the Danish blood donor study

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Scand J Immunol. February 25, 2022: e13150. doi: 10.1111/sji.13150. Online ahead of print.


Familial clustering of primary hyperhidrosis skin disease suggests a genetic component of the disease. Human leukocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No studies have investigated whether HLA genes are involved in the pathogenesis of hyperhidrosis. We therefore compared HLA alleles in individuals with and without hyperhidrosis in this study of 65,000 blood donors. In this retrospective cohort study, we retrieved information on people with and without hyperhidrosis using self-reported questionnaires, the Danish National Patient Register and the Danish National Prescription Register on participants recruited for the Danish Study on blood donors between 2010 and 2019. Association tests using logistic regression were performed for each HLA allele corrected for sex, age, body mass index, smoking and major components. Overall, 145 of 65,795 (0.2%) participants had hospital-diagnosed hyperhidrosis. Similarly, 1379 of 15,530 (8.9%) participants had moderate to severe self-reported hyperhidrosis, of which 447 (2.9%) had self-reported severe hyperhidrosis. A total of 28 participants had both hospital-diagnosed hyperhidrosis and self-reported moderate to severe hyperhidrosis. Self-reported severe hyperhidrosis was associated with HLA-A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32-136.70; n=7; p

PMID:35212011 | DOI:10.1111/sji.13150

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